Description:
AB928 is a dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively. It potently blocks the immunosuppressive effects of high adenosine concentrations in the tumor microenvironment.
Molecular Formula:
C23H22N8O
Canonical SMILES:
CC1=C(C=CC=C1C2=CC(=NC(=N2)N)C3=CN(N=N3)CC4=NC(=CC=C4)C(C)(C)O)C#N
InChI:
InChI=1S/C23H22N8O/c1-14-15(11-24)6-4-8-17(14)18-10-19(28-22(25)27-18)20-13-31(30-29-20)12-16-7-5-9-21(26-16)23(2,3)32/h4-10,13,32H,12H2,1-3H3,(H2,25,27,28)
InChIKey:
BUXIAWLTBSXYSW-UHFFFAOYSA-N
Synonyms:
A2Ar/A2bR antagonist-1; 3-(2-Amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile Más detalles se encuentran
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