BGC > Buscar Producto > 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester | 1144035-53-9
Proveedores de CAS
1144035-53-9
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Identificación | CAS |
1144035-53-9 | Formula |
C22H21Cl2N3O5 |
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6 Proveedores registrados
Amadis Chemical Company Limited
P.R.China
Más detalles se encuentran aquí
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C22H21Cl2N3O5 Molecular Weight: 478.32524 WGKGermany: 3
Aea.ltd
P.R.China
BOC Sciences
USA
Description: PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation. - Molecular Weight:478.33
- Melting Point:149-150°C
- Purity:≥95%
Molecular Formula: C22H21Cl2N3O5 Canonical SMILES: C1CN(CCN1CCC(=O)C2=CC3=C(C=C2)NC(=O)O3)C(=O)OCC4=CC(=CC(=C4)Cl)Cl InChI: InChI=1S/C22H21Cl2N3O5/c23-16-9-14(10-17(24)12-16)13-31-22(30)27-7-5-26(6-8-27)4-3-19(28)15-1-2-18-20(11-15)32-21(29)25-18/h1-2,9-12H,3-8,13H2,(H,25,29) InChIKey: JMSUDQYHPSNBSN-UHFFFAOYSA-N Solubility: Soluble in DMSO Appearance: White to Beige Tan Powder Storage: Store at -20°C Synonyms: 1-Piperazinecarboxylic acid, 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-, (3,5-dichlorophenyl)methyl ester; PF8380; PF 8380; (3,5-Dichlorophenyl)methyl 4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylate; 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester Más detalles se encuentran aquí
Chemlyte Solutions
P.R.China
Más detalles se encuentran aquí
Santa Cruz Biotechnology, Inc.
USA
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