Description:
PFI-3, a potent and selective SMARCA2/4 bromodomain inhibitor, is a cell-permeable probe that binds avidly to the structurally-similar SMARCA4 bromodomain (Kd= 89 nM) and PB1(bromodomain 5) (Kd= 48 nM).
- Molecular Weight:321.38
- Purity:>98%
Molecular Formula:
C19H19N3O2
Canonical SMILES:
C1C2CN(C1CN2C3=CC=CC=N3)C=CC(=O)C4=CC=CC=C4O
InChI:
InChI=1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1
InChIKey:
INAICWLVUAKEPB-QSTFCLMHSA-N
Appearance:
Solid powder
Synonyms:
PFI-3; PFI 3; PFI3. (E)-1-(2-hyd roxyphenyl)-3-[(1R,4R)-2-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-5-yl]prop-2-en-1-one; PF-06687252; PFI-3 compound; PF 06687252; PF06687252 Weitere Informationen finden Sie
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