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Suppliers for
KU-60019
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Properties | CAS |
925701-49-1 | Formula |
C30H33N3O5S |
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6 Registered suppliers
More details are to be found here
Molecular Formula: C30H33N3O5S Molecular Weight: 547.66512
Molecular Formula: C30H33N3O5S Molecular Weight: 547.66512
Description : KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells - Molecular Weight :547.67
- Boiling Point :786.6°C at 760 mmHg
- Purity :98%
Molecular Formula : C30H33N3O5S Canonical SMILES : O=C(NC1=CC(CC2=C(C(C3=CC(C=C(N4CCOCC4)O3)=O)=CC=C2)S5)=C5C=C1)CN6C[C@H](C)O[C@H](C)C6 InChI : 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+ InChIKey : SCELLOWTHJGVIC-BGYRXZFFSA-N Solubility : Soluble in DMSO (100 mM), and ethanol (100 mM). Appearance : White Solid Powder Storage : Store at -20°C Synonyms : KU60019; KU 60019; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
More details are to be found here
Description : KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells - Molecular Weight :547.67
- Boiling Point :786.6°C at 760 mmHg
- Purity :98%
Molecular Formula : C30H33N3O5S Canonical SMILES : O=C(NC1=CC(CC2=C(C(C3=CC(C=C(N4CCOCC4)O3)=O)=CC=C2)S5)=C5C=C1)CN6C[C@H](C)O[C@H](C)C6 InChI : 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+ InChIKey : SCELLOWTHJGVIC-BGYRXZFFSA-N Solubility : Soluble in DMSO (100 mM), and ethanol (100 mM). Appearance : White Solid Powder Storage : Store at -20°C Synonyms : KU60019; KU 60019; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
More details are to be found here
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KU-60019
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Last update 2024-05-17
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