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One of our special products is RESMETIROM - Some additional information:
Molecular Formula: C17H12Cl2N6O4
Molecular weight: 435.22
Density: 1.65±0.1g/cm3(Predicted)
Storage condition: Inertatmosphere,Storeinfreezer,under-20°C
Solubility: DMSO: 59.0 (maximum concentration mg/mL); 135.56 (maximum concentration mM)
Form: Crystalline solid
Acidity coefficient: (pKa)3.96±0.40(Predicted)
Appearance: light yellow solid powder
Product Use: BioactivityResmetirom (MGL-3196,VIA-3196) is a hepatic-directed, orally active, selective thyroidhormonereceptorβ(THR-β) agonist with an EC50 of 0.21 μM and a 28-fold selectivity for THR-β over THR-α.
MGL-3196 has been used in trials for the treatment of non-alcoholic steatohepatitis and heterozygous familial hypercholesterolaemia.
Product specification: 1kg/barrel, 2kg/barrel, 5kg/barrel, 10kg/barrel, 15kg/barrel, 20kg/barrel, 25kg/barrel, etc., and can be separately subcontracted according to customers' requirements.
MGL-3196 Upstream and downstream product information
Upstream products: 4-(Propan-2-yl)pyridazine-3,6-diol
3,6-dichloro-4-isopropylpyridazine; 3,6-dichloro-4-isopropylpyridazine
6-(4-Amino-2,6-dichlorophenoxy)-4-isopropylpyridazin-3(2H)-one
Molecular weight: 435.22
Density: 1.65±0.1g/cm3(Predicted)
Storage condition: Inertatmosphere,Storeinfreezer,under-20°C
Solubility: DMSO: 59.0 (maximum concentration mg/mL); 135.56 (maximum concentration mM)
Form: Crystalline solid
Acidity coefficient: (pKa)3.96±0.40(Predicted)
Appearance: light yellow solid powder
Product Use: BioactivityResmetirom (MGL-3196,VIA-3196) is a hepatic-directed, orally active, selective thyroidhormonereceptorβ(THR-β) agonist with an EC50 of 0.21 μM and a 28-fold selectivity for THR-β over THR-α.
MGL-3196 has been used in trials for the treatment of non-alcoholic steatohepatitis and heterozygous familial hypercholesterolaemia.
Product specification: 1kg/barrel, 2kg/barrel, 5kg/barrel, 10kg/barrel, 15kg/barrel, 20kg/barrel, 25kg/barrel, etc., and can be separately subcontracted according to customers' requirements.
MGL-3196 Upstream and downstream product information
Upstream products: 4-(Propan-2-yl)pyridazine-3,6-diol
3,6-dichloro-4-isopropylpyridazine; 3,6-dichloro-4-isopropylpyridazine
6-(4-Amino-2,6-dichlorophenoxy)-4-isopropylpyridazin-3(2H)-one
Company Profile
Shandong Chenghui Shuangda Pharma (est. 2014) A rapidly growing API/CDMO leader with 200+ synthesis patents and 100MT monthly capacity across 6 cGMP facilities. Holding 22 CDE, 4 FDA DMF, 8 CEP approvals plus NMPA/MFDS/USFDA certifications. Serving 60+ countries with advanced intermediates and custom manufacturing solutions. Third-party patented products for R&D use only
