Description :
LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells.
