Description:
Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50 values of 3.3 nM and 2.8 nM respectively in cell-free assays, and has > 130-fold selectivity for JAK1/2 versus JAK3.
- Molecular Weight: 306.37
- Molecular Formula: C17H18N6
Purity: >98%
Canonical SMILES:
C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
InChI:
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChIKey: HFNKQEVNSGCOJV-OAHLLOKOSA-N
- Melting Point: 84-89°C
- Solubility: Soluble in aqueous buffers across a pH of 1-8
- Appearance: White to Off-white Solid
Synonyms:
(R)-Ruxolitinib; INCB018424; R-INCB018424; (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
More details are to be found on supplier website
