Description:
Letermovir is a novel anti-CMV compound which targets the pUL56 (amino acid 230-370) subunit of the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. It has a novel mode of action targets the enzyme UL56 terminase and keep active to other drug-resistant virus. It has been approved in prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT).
- Molecular Weight: 572.56
- Molecular Formula: C29H28F4N4O4
Purity: ≥98%
Canonical SMILES:
COC1=C(C=C(C=C1)C(F)(F)F)N2C(C3=C(C(=CC=C3)F)N=C2N4CCN(CC4)C5=CC(=CC=C5)OC)CC(=O)O
InChI:
InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1
InChIKey: FWYSMLBETOMXAG-QHCPKHFHSA-N
- Boiling Point: 706.5±70.0 °C at 760 mmHg
- Solubility: In Vivo: 1.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution2.Add each solvent one by one: 10% DMSO >> 90%(20%SBE-β-CDin saline)Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution3.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution
- Appearance: White to Off-white Solid
- Application: Antiviral Agents
- Storage: Powder: -20°C: 3 years4°C: 2 yearsIn solvent: -80°C: 6 months-20°C: 1 month
Synonyms:
AIC246; AIC-246; AIC 246; MK-8828; MK 8828; MK8828
More details are to be found on supplier website
