Molecular Weight: 469.4
Molecular Formula: C22H20F5N3O3
Canonical SMILES: CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChI: InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
InChIKey: OJPLJFIFUQPSJR-INIZCTEOSA-N
Purity: >98%
Solubility: Soluble to 49 mg/mL in DMSO.
Application: Enzyme Inhibitors
Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -44°C for long term (months to years).
Synonyms: RO-4929097; 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
DescriptionRO4929097, a small-molecule inhibitor of γ secretase (IC50 = 4 nM, EC50 = 5 nM), inhibits cellular processing of Aβ40 (EC50 = 14 nM) and Notch (EC50 = 5 nM). It was shown to decrease the levels of Notch transcriptional target HES1 in human primary melanoma cell lines.
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