Molecular Weight: 897.17
Molecular Formula: C44H44CaN2O8S4
Canonical SMILES: CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)[O-])SC3=CC=CC=C3.CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)[O-])SC3=CC=CC=C3.[Ca+2]
InChI: InChI=1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1
InChIKey: NSYUKKYYVFVMST-LETVYOFWSA-L
Boiling Point: 646.3°C at 760 mmHg
Melting Point: >250°C
Purity: 95%
Solubility: 10 mM in DMSO
Application: Zofenopril Calcium promotes the regeneration of peripheral nerve injuries in rat models. lt increases SR calcium cycling and stimulates active calcium uptake into the SR.
Storage: -20°C Freezer
Synonyms: SQ26991; SQ 26991; SQ-26991; (4S)-N-[3-(benzoylsulfanyl)-2(s)-methylpropionyl]-4-(phenylsulfanyl)-l-proline calcium salt;[1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl Ester Calcium Salt;[(4S)-(2S)-3-(benzoylthio)-2-methylpro-pionyl-4-(phenylthio)-L-prolinelcalcium;Calcium;(2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylate
DescriptionZofenopril Calcium is an antioxidant and acts as an angiotensin-converting enzyme (ACE) inhibitor. lt is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus. lt is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat. lt promotes the regeneration of peripheral nerve injuries in rat models. lt increases SR calcium cycling and stimulates active calcium uptake into the SR. It was developed by the Bristol Myers Squibb Company.
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