CAS No. 668270-12-0

Molecular Formula: C25H28N8O2
Molecular Weight: 472.54
HS Code: 29335990

Category:Working Standards
Purity:98,68%

EINECS:1308068-626-2
Molecular formula:C25H28N8O2

Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.717
Storage condition	2-8C

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
Cell Assay
A total of 4.0×107 keratinocytes per well are seeded into 24-well plates. After reaching 50% confluence, cells are starved for 24 h with DMEM. Proliferation of cells is assessed by using 1 μCi/mL of [3H]methyl-thymidine in DMEM in the presence of 10% fetal bovine serum and increasing concentrations of linagliptin (3, 30, 300, or 600 nM) for 24 h. Cells are then washed twice with phosphate-buffered saline and incubated in 5% trichloroacetic acid at 4°C for 30 min, and the DNA is solubilized in 0.5mol/LNaOH for 30 min at 37°C. Finally, [3H]thymidine incorporation is determined.

Molecular Weight: 472.553
Molecular Formula: C25H28N8O2
Canonical SMILES: CC4=NC5=CC=CC=C5C(=N4)C)C
InChI: InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
InChIKey: LTXREWYXXSTFRX-QGZVFWFLSA-N
Melting Point: 190-196°C
Purity: 98%
Application: the treatment of type 2 diabetes
Synonyms: Tradjenta; BI-1356; BI 1356; BI1356; Ondero; Trajenta
Description
Linagliptin is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.


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