Description:
Apremilast is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast specifically inhibits PDE4 and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells.
- Molecular Weight: 460.50
- Molecular Formula: C22H24N2O7S
Purity: >98%
Canonical SMILES:
CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
InChI:
InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
InChIKey: IMOZEMNVLZVGJZ-QGZVFWFLSA-N
- Boiling Point: 741.3±60.0°C (Predicted)
- Melting Point: 154-156 °C
- Solubility: Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- Appearance: Off-White to Pale Yellow Solid
- Application: Anti-inflammatory agents, Non-steroidal; phosphodiesterase inhibitors
- Storage: Store at 2-8°C
Synonyms:
(S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione; (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; CC 10004; CC10004; CC-10004
More details are to be found on supplier website
