Molecular Weight: 451.34
Molecular Formula: C22H24Cl2N2O4
Canonical SMILES: C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
InChI: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChIKey: HJGMCDHQPXTGAV-UHFFFAOYSA-N
Boiling Point: 719.0±60.0 °C | Condition: Press: 760 Torr
Solubility: Soluble to 10 mM in DMSO with gentle warming
Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -42°C for long term (months to years).
Synonyms: Acetamide, N,N'-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-
ISRIB compound
DescriptionISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated.
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