Description:
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Betulinic acid is a natural compound found in the herbs of Ziziphus jujuba. It can be used in cosmetics material.
- Molecular Weight: 456.7
- Molecular Formula: C30H48O3
Purity: 0.98
Canonical SMILES:
CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O
InChI:
InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
InChIKey: QGJZLNKBHJESQX-FZFNOLFKSA-N
- Boiling Point: 550.0±33.0 °C at 760 mmHg
- Melting Point: 295-298 °C (dec.)(lit.)
- Solubility: In Vitro: DMSO : 35.71 mg/mL(78.19 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% salineSolubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic2.Add each solvent one by one: 10% DMSO >> 90% (20%SBE-β-CDin saline)Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic3.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 2.08 mg/mL (4.55 mM); Clear solution
- Appearance: White to off-white Solid
- Application: Anti-melanogenic/antitumor/anti-HIV
- Storage: 4°C, protect from light* In solvent : -80°C, 6 months-20°C, 1 month (protect from light)
Synonyms:
ALS357; ALS 357; ALS-357; Mairin; Acronym: BA; Code name: ALS-357.
More details are to be found on supplier website
