Description:
Steviol is a diterpenoiic carboxylic alcohol and is isolated from the herbs of Stevia rebaudiana. It is the aglycon derivative of natural sweetener steviol glycosides and is found to be highly mutagenic compared to Stevioside. It inhibits the proliferation of the gastrointestinal cancer cells and the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. It also inhibits human organic anion transporters (hOATs) in uptake assays using murine cells from the S2 segment of proximal tubules. It is selective for hOAT1 and hOAT3 over hOAT2 and hOAT4. It increases CYP3A29 expression and enhances pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. It can be used to treat polycystic kidney disease. It can promote proteasome and lysosome-mediated AQP2 degradation and slow cyst growth by reducing AQP2 transcription.
- Molecular Weight: 318.45
- Molecular Formula: C20H30O3
Purity: 98.5%
Canonical SMILES:
CC12CCCC(C1CCC34C2CCC(C3)(C(=C)C4)O)(C)C(=O)O
InChI:
InChI=1S/C20H30O3/c1-13-11-19-9-5-14-17(2,7-4-8-18(14,3)16(21)22)15(19)6-10-20(13,23)12-19/h14-15,23H,1,4-12H2,2-3H3,(H,21,22)/t14?,15?,17-,18-,19-,20+/m1/s1
InChIKey: QFVOYBUQQBFCRH-HFQBERHNSA-N
- Boiling Point: 464.5±45.0 °C at 760 mmHg
- Appearance: Powder
Synonyms:
(4α)-13-Hydroxy-kaur-16-en-18-oic Acid; 13-Hydroxy-kaur-16-en-18-oic Acid; 13-Hydroxykaurenoic Acid; Ent-13-hydroxy-kauran-16-en-19-oic Acid; 1H-2,10a-Ethanophenanthrene; 13-O-Glucosylsteviol; Hydroxydehydrostevic Acid; (4R,4aS,6aR,9S,11aR,11bS)-9-hydroxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
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