Description:
Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
- Molecular Weight: 411.62
- Molecular Formula: C27H41NO2
Purity: >98%
Canonical SMILES:
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
InChI:
InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChIKey: QASFUMOKHFSJGL-LAFRSMQTSA-N
- Boiling Point: 550.8°C at 760 mmHg
- Melting Point: >235°C (dec.)
- Solubility: Soluble in Chloroform, Dichloromethane, Ethanol (20 mg/mL ), DMSO (4 mg/ml), DMF (10 mg/mL)
- Appearance: White Crystal Powder
- Storage: Store at -20°C
Synonyms:
HSDB-3505; HSDB 3505; HSDB-3505; 11-Deoxojervine
More details are to be found on supplier website
