Molecular Weight: 608.72
Molecular Formula: C37H40N2O6
Canonical SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)O)OC)OC
Boiling Point: 709.7±60.0 °C at 760 mmHg
Purity: >98%
Solubility: In Vitro:
DMSO : 50 mg/mL(82.14 mM;Need ultrasonic)
In Vivo:
1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline
Solubility: ≥ 2.08 mg/mL (3.42 mM); Clear solution
2.Add each solvent one by one:10% DMSO >> 90%corn oil
Solubility: ≥ 2.08 mg/mL (3.42 mM); Clear solution
Application: abirritation and antiinflammation
Storage: 4°C, protect from light
* In solvent :
-80°C, 6 months
-20°C, 1 month (protect from light)
Synonyms: 7-o-demethyltetrandrine; 6,6',12-Trimethoxy-2,2'-Dimethylberbaman-7-ol; (+)-Fangchinoline; Fangchino-line
DescriptionSource from vines of Cocculus orbiculatus (L.) DC. Fangchinoline inhibits the production of infectious virions in HIV-1 cDNA transfected 293T cells. It induces G1 arrest in breast cancer cells through cell-cycle regulation.
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