Molecular Weight: 350.44
Molecular Formula: C19H18N4OS
Canonical SMILES: CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
Purity: 98%
Application: Differentiation
Synonyms: JK184; JK 184
DescriptionJK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity.
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