Description:
Geldanamycin is a benzoquinone ansamycin antibiotic that inhibits heat shock protein 90 (HSP90). Geldanamycin has been shown to promote survival of neural stem cells from oxidative stress via inhibition of HSP90. It displays potent antineoplastic properties and inhibits myeloma cell growth.
- Molecular Weight: 560.64
- Molecular Formula: C29H40N2O9
Purity: >98%
Canonical SMILES:
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
InChI:
InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
InChIKey: QTQAWLPCGQOSGP-KSRBKZBZSA-N
- Boiling Point: 627.87°C at 760 mmHg
- Melting Point: 252-255°C
- Solubility: DMSO ≥ 110mg/mL H2O < 1.2mg/mL Ethanol < 1.2mg/mL
- Appearance: Solid Powder
- Application: Antibiotics, Antineoplastic
- Storage: 3 years -20°C powder, 6 months -80°C in solvent.
Synonyms:
geldanomycin; NSC 122750; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
More details are to be found on supplier website
