CAS No. 2097132-94-8

Description:
BLU-667 (Pralsetinib) is a highly effective and selective RET inhibitor. It has an IC50 of 0.3-0.4 nM for the fusion of WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET.

• Molecular Weight: 533.6
• Molecular Formula: C27H32FN9O2

Purity: ≥98% by HPLC

Canonical SMILES:
CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)NC(C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC

InChI:
InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t18-,19?,27?/m0/s1

InChIKey: GBLBJPZSROAGMF-SIYOEGHHSA-N

• Boiling Point: 799.1±60.0 °C(Predicted)
• Solubility: Soluble in DMSO
• Storage: Store at -20°C

Synonyms:
Pralsetinib

More details are to be found on supplier website

Smile code:
O=C([C@@]1(OC)CC[C@@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C
MDL Number:
MFCD31810155
Purity :
99%
Available in stock:
11.211 g