Description:
Bremelanotide is a peptide melanocortin receptor agonist developed for the treatment of sexual dysfunction, hemorrhagic shock and reperfusion injury.
- Molecular Weight: 1025.16
- Molecular Formula: C50H68N14O10
Canonical SMILES:
CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C
InChI:
InChI=1S/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
InChIKey: FFHBJDQSGDNCIV-MFVUMRCOSA-N- Appearance: White Powder
- Application: Bremelanotide is a synthetic peptide drug that has generated a lot of interest in the drug development community due to its potential applications in sexual dysfunction and other conditions. This peptide is a synthetic analog of the natural hormone alpha-MSH (melanocyte stimulating hormone) and acts as a non-selective agonist of the melanocortin receptors MC3-R and MC4-R. One of the main areas of application of bremelanotide in drug development is the treatment of female sexual dysfunction, specifically hypoactive sexual desire disorder (HSDD). HSDD is a disorder characterized by a persistent lack of sexual desire and associated distress that is not associated with any known medical or psychiatric condition. Bremelanotide has shown promising results in clinical trials for the treatment of HSDD, demonstrating its ability to increase sexual desire and arousal in women.In addition to its potential role in treating female sexual dysfunction, bremelanotide has also shown promise in the treatment of other conditions. For example, studies have explored the use of bremelanotide in the treatment of male erectile dysfunction, as well as its potential use in obesity, inflammation, and cardiovascular disease. The melanocortin system targeted by Bremelanotide plays a crucial role in regulating a variety of physiological processes, making this peptide a valuable tool for researchers exploring new therapeutic avenues.From a drug discovery perspective, the development of Bremelanotide as a drug involves a multifaceted approach, including molecular design, preclinical testing, clinical trials, and regulatory approval. The initial steps in the drug discovery process include the design of synthetic analogs of alpha-MSH that exhibit improved pharmacokinetic properties, such as enhanced stability, specificity, and bioavailability. Through structure-activity relationship studies and computational modeling, researchers can optimize Bremelanotide's molecular structure to enhance its therapeutic effects.
- Storage: Store at -20°C
Synonyms:
(Ac-Nle4, Asp5, D-Phe7, Lys10)-cyclo-α-MSH (4-10); PT 141; PT-141; PT141
More details are to be found on supplier website
