CAS No. 177036-94-1

Molecular Formula: C22H22N2O4
Molecular Weight: 378.42
HS Code: 29335990

Molecular Weight: 378.42
Molecular Formula: C22H22N2O4
Canonical SMILES: CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI: InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
InChIKey: OUJTZYPIHDYQMC-LJQANCHMSA-N
Melting Point: >150 °C
Purity: >98%
Solubility: Ambrisentan is practically insoluble in aqueous solutions at low pH. Solubility increases at higher pH.
Application: Antihypertensive Agents
Synonyms: BSF-208075; BSF208075; BSF 208075; LU-208075; LU208075; LU 208075; Letairis; Volibris
Description
Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).


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