Description:
Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM)3, and inhibits hepatitis B and hepatitis C virus replication (EC50s both = 0.15 μM).
- Molecular Weight: 265.25
- Molecular Formula: C10H7N3O4S
Purity: >98%
Canonical SMILES:
C1=CC=C(C(=C1)C(=O)NC2=NC=C(S2)[N+](=O)[O-])O
InChI:
InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)
InChIKey: FDTZUTSGGSRHQF-UHFFFAOYSA-N
- Melting Point: >240 °C (dec)
- Solubility: 10 mM in DMSO
- Appearance: White to Off-white Solid
- Application: Anti-Infective Agents
- Storage: - 20 °C
Synonyms:
TIZ; NSC-697856; NSC697856; NSC697856; Tizoxanide; Desacetylnitazoxanide; Desacetyl-nitazoxanide.
More details are to be found on supplier website
