Molecular Weight: 451.34
Molecular Formula: C22H24Cl2N2O4
Canonical SMILES: C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
InChI: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChIKey: HJGMCDHQPXTGAV-UHFFFAOYSA-N
Boiling Point: 719±60.0°C(Predicted)
Solubility: Soluble to 10 mM in DMSO with gentle warming
Storage: 2 - 8 °C
Synonyms: 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide; 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide; ISRIB compound; trans-ISRIB
DescriptionISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated.
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