Molecular Weight: 214.05
Molecular Formula: C5H9Cl2N3O2
Canonical SMILES: C(CCl)NC(=O)N(CCCl)N=O
InChI: InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChIKey: DLGOEMSEDOSKAD-UHFFFAOYSA-N
Purity: ≥98%
Synonyms: 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin
DescriptionCarmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas.
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