CAS No. 129496-10-2

Molecular Formula: 2C32H45NO7.2C31H43NO7
Molecular Weight: 2194.78
UN Number: 2588
WGKGermany: 3
PackingGroup: III
HS Code: 2932206000

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Description: White or light yellow powder
Solubility: Practically insoluble, very soluble in acetonitrile, in anhydrous ethanol and in ethyl acetate.

Identification
Infrared Identification: Infrared absorption chromatograph obtained with the test solution should be consistent with that of the reference standard solution
HPLC Identification: The retention time of the major peaks of the sample solution should correspond to that of the reference standard solution.

Residue on Ignition: ≤0.5%
Water content: ≤2.0%
Heavy meta: ≤30ppm

Related Substances
Impurity G: ≤2.0%
Impurity E: ≤0.7%
Impurity H: ≤0.5%
Impurity I: ≤0.5%
Any other impurities: ≤0.2%
Total impurities: ≤3.5%

Assay
A3+A4: 95.0%~102.0%
A3 Ratio: ≤0.20
A4 Ratio: ≥0.80

Residual solvents
Ethanol: ≤5000ppm
Acetone: ≤5000ppm
n-Heptane: ≤5000ppm
Methanol: ≤3000ppm
4-Dioxane: ≤380ppm
Methylene chloride:≤600ppm
Chloroform: ≤60ppm

Description:
Milbemycin oxime is a semi-synthetic macrolide. As a nematocide and insecticide in veterinary medicine, it opens glutamate sensitive chloride channels in neurons of invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer blocking. M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); Bile acid transporter: IC50 = 3.6 µM (human); TGR5: IC50 = 36.4 µM (human); HCT-116: IC50 >50 µM (human); GBM: IC50 >50 µM (human)

• Molecular Weight: 2194.78
• Molecular Formula: C126H176N4O28

Purity: ≥98%

Canonical SMILES:
CCC1C(CCC2(O1)CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)C.CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)OC1C

InChI:
InChI=1S/C32H45NO7.C31H43NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3

InChIKey: CKVMAPHTVCTEMM-UHFFFAOYSA-N

• Melting Point: 169.6-177.4°C
• Solubility: Soluble in DMSO, not in water
• Appearance: White Powder
• Application: A broad spectrum insecticide; Used for treatment and prevention of heartworm in dogs and cats
• Storage: Store at -20°C, Under inert atmosphere

Synonyms:
Milbemycin A 5-oxime; Milbemite; Trifexis; Interceptor; Milbe Mite

More details are to be found on supplier website