Description:
Losartan is an angiotensin II receptor antagonist that competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. It promotes vasodilatation and counteracts the effects of aldosterone thus can be used as an antihypertensive.
- Molecular Weight: 462.01
- Molecular Formula: C22H23ClKN6O
Purity: >98%
Canonical SMILES:
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]
InChI:
InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
InChIKey: OXCMYAYHXIHQOA-UHFFFAOYSA-N
- Boiling Point: 682 °C
- Melting Point: >259°C (subl.)
- Appearance: White to Off-White Solid
- Application: antihypertensive
Synonyms:
MK 954; MK954; MK-954; Cozaar; Lorzaar; Losaprex; Hyzaar; [2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
More details are to be found on supplier website
