Description:
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.
- Molecular Weight: 405.35
- Molecular Formula: C19H17F2N3O5
Purity: >98%
Canonical SMILES:
CC1COC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
InChI:
InChI=1S/C19H17F2N3O5/c1-9-8-29-14-7-23-6-12(16(25)17(26)15(23)19(28)24(9)14)18(27)22-5-10-2-3-11(20)4-13(10)21/h2-4,6,9,14,26H,5,7-8H2,1H3,(H,22,27)/t9-,14+/m0/s1
InChIKey: WCWSTNLSLKSJPK-LKFCYVNXSA-N
- Boiling Point: 664.0±55.0 °C at 760 mmHg
- Solubility: In Vitro: DMSO : 16.67 mg/mL(41.12 mM;Need ultrasonic)In Vivo: 1.Add each solvent one by one: 10% DMSO >> 90%corn oilSolubility: ≥ 1.67 mg/mL (4.12 mM); Clear solution
- Appearance: White to off-white (Solid)
- Application: HIV Integrase Inhibitors
- Storage: Store at -20°C
Synonyms:
S/GSK1265744; S/GSK 1265744; S/GSK-1265744; GSK744; GSK-744; GSK 744; Cabotegravir.
More details are to be found on supplier website
