CAS No. 104196-68-1

Molecular Formula: C36H44N4O
Molecular Weight: 548.771

Molecular Weight: 548.76
Molecular Formula: C36H44N4O
Canonical SMILES: O[C@]1(CC/C=CCCCC2)[C@@]3([H])[C@@](C[C@@]4([H])N3CCCC/C=C4)(C[N@@]2CC5)[C@]5([H])C(C6=C(NC7=CC=CC=C87)C8=CC=N6)=C1
InChI: InChI=1S/C36H44N4O/c41-36-18-10-4-1-2-5-11-20-39-22-17-30(35(25-39)23-26-13-7-3-6-12-21-40(26)34(35)36)29(24-36)32-33-28(16-19-37-32)27-14-8-9-15-31(27)38-33/h1,4,7-9,13-16,19,24,26,30,34,38,41H,2-3,5-6,10-12,17-18,20-23,25H2/b4-1-,13-7-/t26-,30-,34+,35-,36-/m0/s1
InChIKey: FUCSLKWLLSEMDQ-MKYGIPPKSA-N
Purity: ≥98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
Synonyms: Manzamine A;104196-68-1;CHEMBL403233;Keramamine A;CHEBI:66667;(4aR,7S,7aR,13Z,14aR,15aR,18Z)-5-(9H-beta-carbolin-1-yl)-4,4a,9,10,11,12,14a,15-octahydro-3H-7,2-oct[3]enoazocino[1',2':1,5]pyrrolo[2,3-i]isoquinolin-7(1H,7aH)-ol;MANZAMINE;CHEMBL326531;SCHEMBL14377624;DTXSID001098329;BDBM50232478;AKOS040748872;HY-117025;CS-0063523;Q27135285;(1R,2R,4R,5Z,12R,13S,16Z)-25-(9H-pyrido[3,4-b]indol-1-yl)-11,22-diazapentacyclo[11.11.2.12,22.02,12.04,11]heptacosa-5,16,25-trien-13-ol;(1R,4S,9Z,13S,13aR,20aR,21aR)-2,3,5,6,7,8,11,12,15,16,17,18,20a,21-Tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-1,13-etheno-4,21a-methano-1H-azocino[1a(2),2a(2):1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol;
Description
Manzamine A is an alkaloid in the class of β-carboline isolated from the marine sponges. It acts as an inhibitor of glycogen synthase kinase 3β (GSK3β). It exhibits inhibitory effects against growth of the rodent malaria parasite Plasmodium berghei in vivo.


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