BGC > Product Search > Lonafarnib | 193275-84-2

Appearance	white powder
Purity (gc area %)	≥ 98.5%
H NMR	Conforms to structure

Molecular Formula: C27H31Br2ClN4O2
Molecular Weight: 638.82164

Description:
Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers.

• Molecular Weight:638.829
• Melting Point:150-152°C
• Purity:> 95%

Molecular Formula:
C27H31Br2ClN4O2
Canonical SMILES:
C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
InChI:
InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
InChIKey:
DHMTURDWPRKSOA-RUZDIDTESA-N
Solubility:
~3mg/ml
Appearance:
white solid powder
Application:
Enzyme Inhibitors
Synonyms:
SCH 66336; SCH-66336; SCH66336; Sarasar