Description:
Benzamil hydrochloride is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM) and an epithelial sodium channel (ENaC) blocker. Benzamil is an analogue of amiloride, and it is potentially used for the treatment of cystic fibrosis.
- Molecular Weight:356.21
- Purity:≥98% by HPLC
Molecular Formula:
C13H14ClN7O.HCl
Canonical SMILES:
C1=CC=C(C=C1)CN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N.Cl
InChI:
InChI=1S/C13H14ClN7O.ClH/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H
InChIKey:
ZNWMRWWNJBXNKJ-UHFFFAOYSA-N
Application:
potential treatment of cystic fibrosis
Synonyms:
N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride More details are to be found
here