Description:
Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition.
- Molecular Weight:446.90
- Boiling Point:586.8±50.0°C (Predicted)
- Melting Point:192-194°C
- Purity:>98%
Molecular Formula:
C22H24ClFN4O3
Canonical SMILES:
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
InChI:
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChIKey:
XGALLCVXEZPNRQ-UHFFFAOYSA-N
Solubility:
Slightly soluble in DMSO, Methanol (Heated)
Appearance:
White to Off-white Solid
Storage: Store at -20°C
Synonyms:
ZD1839; ZD 1839; ZD-1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa; gefitinibum More details are to be found
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