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Suppliers for
Afatinib
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Properties | | CAS |
850140-72-6 | | Formula |
C24H25ClFN5O3 |
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8 Registered suppliers
More details are to be found here
More details are to be found here
Molecular Formula: C24H25ClFN5O3
Molecular Weight: 485.9384032
HS Code: 29420000
More details are to be found here
More details are to be found here
Description : Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. - Molecular Weight :485.94
- Boiling Point :676.9±55.0°C at 760 mmHg
- Melting Point :> 140°C (dec.)
- Purity :> 98%
Molecular Formula : C24H25ClFN5O3 Canonical SMILES : CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
InChI :
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChIKey :
ULXXDDBFHOBEHA-CWDCEQMOSA-N
Solubility :
Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated)
Appearance :
White to Pale Yellow Solid
Application :
Antineoplastic Agents
Storage : Store at -20°C
Synonyms :
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
More details are to be found here
Description : Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. - Molecular Weight :485.94
- Boiling Point :676.9±55.0°C at 760 mmHg
- Melting Point :> 140°C (dec.)
- Purity :> 98%
Molecular Formula : C24H25ClFN5O3 Canonical SMILES : CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
InChI :
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChIKey :
ULXXDDBFHOBEHA-CWDCEQMOSA-N
Solubility :
Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated)
Appearance :
White to Pale Yellow Solid
Application :
Antineoplastic Agents
Storage : Store at -20°C
Synonyms :
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
More details are to be found here
Detailed information on the suppliers of
Afatinib |
Properties:
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Last update 2024-04-24
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