BGC > Product Search > Sirolimus | 53123-88-9

Molecular Formula: C51H79NO13
Molecular Weight: 914.18
Hazard Symbols: Xi,Xn,F
UN Number: UN 1648 3 / PGII
WGKGermany: 2
HS Code: 29349990

Molecular formula: C53H84NO14P

Molecular Fomula	C51H79NO13
Molecular weight	914.18
Appearance	Odorless,off-white to yellow crystalline powder
Assay	98%

Appearance	Odorless,off-white to yellow crystalline powder
Specific rotation	-147°~-157°
Solubility	Freely soluble in methanol or chloroform ,practical insoluble in water Conform Identification A The IR spectrum of Potassium Bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard. Conform Identification B The UV spectrum of 95% Ethanol preparation of the sample exhibits maxima at 267nm,277nm,288nm that of a similar preparation of in-house reference standard. Conform Identification C The retention times of the peaks for the Trans- and Cis -stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the Assay.
Loss On Dry	Not More Than 0.50% 0.18%
Heavy Metals	Not More Than 0.002%
Chromatographic Purity	Individual Impurity Not More Than 1.0%
Impurities	Not More Than 2.0%
Cis-Stereoisomer of Sirolimus	Not More Than 5.0%

Assay:99.0%min

Description:
Rapamycin is an mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines.

• Molecular Weight:914.19
• Boiling Point:973.0°C at 760 mmHg
• Melting Point:183-185°C
• Purity:>98%

Molecular Formula:
C51H79NO13
Canonical SMILES:
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
InChI:
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChIKey:
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Solubility:
Soluble in DMSO (25 mg/ml), ethanol (up to 50 mg/ml), chloroform (5 mg/ml), methanol (25 mg/ml), ether, and acetone. Limited water solubility.
Appearance:
White Crystalline Powder
Application:
antifungal and antineoplastic agent
Storage: Store at -20°C
Synonyms:
Sirolimus; (-)-Rapamycin; AY 22989; AY-22989; I-2190A; NSC 226080; RAPA; RAP; RPM; SLM; WY-090217; Everolimus EP Impurity A

Purity: 98%
Smile code: O=C(C([C@](O[C@]1([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H]2C)OC)([C@@H](CC1)C)O)=O)N(CCCC3)[C@]3([H])C(O[C@](CC([C@@H](/C=C([C@H]([C@H](C([C@H](C)C2)=O)OC)O)C)C)=O)([H])[C@H](C)C[C@H](CC[C@H]4O)C[C@H]4OC)=O
MDL Number: MFCD00867594
MolFormula: C51H79NO13
MolWeight: 914.1719
Available in stock: 406.915

Smile code:
O=C(C([C@](O[C@]1([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H]2C)OC)([C@@H](CC1)C)O)=O)N(CCCC3)[C@]3([H])C(O[C@](CC([C@@H](/C=C([C@H]([C@H](C([C@H](C)C2)=O)OC)O)C)C)=O)([H])[C@H](C)C[C@H](CC[C@H]4O)C[C@H]4OC)=O
MDL Number:
MFCD00867594
Purity :
98%
Available in stock:
411.615 g