BGC > Product Search > LEE011 | 1211441-98-3

Molecular Formula: C22H29ClN8
Molecular Weight: 440.97226

Description:
Ribociclib, also known as LEE011, is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

• Molecular Weight:434.55

Molecular Formula:
C23H30N8O
Canonical SMILES:
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
InChI:
InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChIKey:
RHXHGRAEPCAFML-UHFFFAOYSA-N
Appearance:
Yellow Solid
Synonyms:
LEE011; LEE 011; LEE-011; Kisqali

Purity: 98%
Smile code: O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C
MDL Number: MFCD27976795
MolFormula: C23H30N8O
MolWeight: 434.5373
Available in stock: 229.789

Smile code:
O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C
MDL Number:
MFCD27976795
Purity :
98%
Available in stock:
214.167 g