BGC > CAS Search > 606-68-8

Molecular Formula: C21H27N7Na2O14P2
Molecular Weight: 709.4
Hazard Symbols: Xn
WGKGermany: 3
HS Code: 29349990

Molecular Formula: C21H29N7Na2O15P2
Molecular Weight: 727.42

Description:
NADH becomes oxidized to produce NAD+, NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Nutritional supplement in health care products.

• Molecular Weight:709.41
• Melting Point:>188 °C
• Purity:≥92%

Molecular Formula:
C21H27N7Na2O14P2
Canonical SMILES:
C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OCC3C(C(C(O3)N4C=NC5=C4N=CN=C5N)O)O)O)O.[Na+].[Na+]
InChI:
1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+
InChIKey:
QRGNQKGQENGQSE-WUEGHLCSSA-L
Solubility:
Soluble in DMSO
Appearance:
Off-White Solid
Application:
Ingredient of health care products.
Storage: Store at -20 °C
Synonyms:
β-Nicotinamide adenine dinucleotide disodium salt; disodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;

Purity: 98%
Smile code: NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP([O-])(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C=C(C(N)=O)CC=C5)O4)=O)([O-])=O)O3)C=N2)=NC=N1.[Na+].[Na+]
MDL Number: MFCD00036200
MolFormula: C21H27N7Na2O14P2
MolWeight: 709.4047
Available in stock: 656.061

Smile code:
NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP([O-])(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](N5C=C(C(N)=O)CC=C5)O4)=O)([O-])=O)O3)C=N2)=NC=N1.[Na+].[Na+]
MDL Number:
MFCD00036200
Purity :
98%
Available in stock:
636.159 g

Product name: Beta-NADH
As a coenzyme of dehydrogenase, NADH participates in hundreds of redox reactions in cells. NADH is converted into NAD+ after being oxidized, providing cells with NAD+, the key anti-aging molecule.

The more NADH in the cell, the more energy molecule ATP is produced, the better the cell function and the longer the cell life. As we age, cells age because of insufficient energy to maintain normal metabolism and repair functions. If NADH is added to cells, it can provide cells with energy and repair dual protection. The human body has a greater demand for NADH for energy-consuming organs.

Mechanism 1: boost energy
Most of the physiological processes of cells (such as protein synthesis, DNA repair, insulin synthesis and secretion, immune response, cell division, etc.) require the energy molecule ATP to drive. ATP will be continuously and rapidly consumed and produced cyclically. The production process of ATP requires sufficient NADH support. The human body stores less than 100g of ATP at all times, but consumes as much as 100kg of ATP every day. The production of ATP must be very efficient to maintain the normal operation of cell functions. Therefore, the more NADH in the cell, the more sufficient energy ATP is produced by the cell.

Published experimental studies have confirmed that cells can use exogenous supplementation of NADH to increase cell energy levels. Athletes taking NADH can increase oxygen availability, increase muscle energy supply, and shorten reaction time. Patients with chronic fatigue syndrome can improve fatigue and reduce anxiety and psychological stress after taking NADH.

Mechanism 2: Antioxidant
NADH is the strongest antioxidant substance in mitochondria. NADH\'s antioxidant effect is reflected in the following aspects: 1. NADH\'s own reducing effect can directly remove some free radicals;
2. NADH can regenerate oxidized coenzyme Q10 and glutathione Peptides, etc., to restore their antioxida nt capacity; 3. NADH can be transformed into other forms such as NAD+ and NADPH through the action of enzymes, which can activate other antioxidant pathways in the cell.

Experiments comparing NADH and ascorbic acid (vitamin C) against LDL oxidation showed that NADH can resist LDL oxidation more durable than vitamin C. Preventing oxidation of low-density lipoprotein helps prevent vascular endothelial damage and the formation of atherosclerosis.

Experiments have also confirmed that NADH can remove hydrogen peroxide in nerve cells and help prevent neurodegenerative diseases (such as Alzheimer\'s disease). Human clinical trials have found that patients with Alzheimer\'s who take NADH have improved language fluency, memory and cognitive abilities.

Mechanism 3: Promote the synthesis of neurotransmitter
NADH promotes the synthesis of neurotransmitters dopamine, serotonin and norepinephrine. Dopamine is a neurotransmitter that makes people feel happy or excited. When the concentration of dopamine in the brain is reduced, the central excitement is weakened, and the person\'s responsiveness is reduced, the ability to control muscles is reduced, and the mood is also low. Lack of dopamine in certain areas of the brain causes Parkinson\'s disease. Clinically, Parkinson\'s disease is improved mainly by restoring dopamine levels. The clinical application of NADH began as an aid in the treatment of Parkinson’s disease. Thousands of human clinical trials have found that NADH can improve the ability of Parkinson’s patients. The reason may be that NADH increases the activity of tyrosine hydroxylase in cells and stimulates dopamine. Biosynthesis is related.



Mechanism 4: repair cells
After NADH releases biological hydrogen and supplies energy for ATP synthesis, it is oxidized to NAD+, replenishing the cell\'s NAD+ pool. As the only coenzyme of DNA repair enzyme PARP1, NAD+ is an essential substance involved in DNA repair. DNA damage and repair processes exist in cells at all times. Repairing DNA damage in time can avoid further cell damage and dysfunction. As people get older, DNA damage increases, and the level of NAD+ in the body decreases, and DNA damage gradually accumulates, which will cause damage to cell structure and function, and damage to a large number of cells will lead to the decline of tissue and organ function. Cause human aging and disease, even cancer.

The repairing effect of NADH has been confirmed through experiments to help protect cells, tissues and organs against ultraviolet rays, radiation, harmful chemicals, etc.

Efficacy five: alcohol metabolism
Alcohol metabolism is divided into two steps. First, it is converted into toxic acetaldehyde, and then further decomposed into harmless acetic acid. Each step must rely on the catalysis of oxidized NADH.

At present, several NADH health products are on the market. According to relevant statistics, the effects of individual cases reported by users are very diverse, including: energy improvement, physical strength improvement, fat reduction, muscle increase, exercise capacity enhancement, skin improvement, hair loss reduction, hair growth, Sleep improvement, circadian clock regulation, immune regulation, allergy reduction, sexual function enhancement, appetite boost, visual fatigue reduction, vision improvement, mood improvement, decrease in high blood sugar, decrease in hypertension, systolic blood pressure, normalization of hypotension, improvement of constipation, etc., It varies from person to person.

This component belongs to the family of Enzyme