BGC > CAS Search > 104344-23-2

Appearance	White crystals or a white crystalline powder
Identification	1) Corresponds to that of Bisoprolol Fumarate reference standard. 2) The retention time of the major peak in the chromatofram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation as obtained in the Assay.
Specific rotation	-2°~ +2°
Water determination	≤ 0.5%
Reside on ignition	≤ 0.1%
Heavy metals	≤ 0.002%
Chromatographic purity	Total impurities ≤ 0.5%
Content of Fumaric Acid	14.8 ~ 15.4% calculated on the anhydrous basis
Residual Solvents
2-propanol	≤ 5000ppm
Epichlorohydrin	≤ 100ppm
Benzene	≤ 2ppm
Methanol	≤ 3000ppm
Methyl tertbutyl ether	≤ 5000ppm
Ethanol	≤ 5000ppm
Ethyl acetate	≤ 5000ppm
Assay	97.5% ~ 102.0% calculated on the anhydrous basis

Molecular Formula: C22H35NO8
Molecular Weight: 441.5152

Description:
Bisoprolol is a beta-adrenoceptor blocking drug (beta-blocker). More specifically, it is a selective type β1 adrenergic receptor blocker.

• Molecular Weight:383.48
• Melting Point:99-102°C
• Purity:>98%

Molecular Formula:
C18H31NO4.1/2(C4H4O4)
Canonical SMILES:
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI:
InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChIKey:
VMDFASMUILANOL-WXXKFALUSA-N
Solubility:
Soluble in Chloroform (Slightly), Ethanol, Methanol (Slightly)
Appearance:
White to Off-white Solid
Application:
Antihypertensive Agents
Storage: Store at 2-8°C
Synonyms:
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate; Bisoprolol Fumarate; Concor; Detensiel; Emcor; Euradial; Isoten; Monocor; Soprol; Zebeta; Fondril; (+/-)-Bisoprolol hemifumarate; 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt); 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (±)-, (E)-2-butenedioate (2:1) (salt); 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate; EMD 33512; Emvoncor; Maintate