BGC > Product Search > Panobinostat | 404950-80-7

Molecular Formula: C21H23N3O2
Molecular Weight: 349.42622
HS Code: 29339900

Description:
Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.

• Molecular Weight:349.434
• Melting Point:114-117?C
• Purity:>98%

Molecular Formula:
C21H23N3O2
Canonical SMILES:
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
InChI:
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChIKey:
FPOHNWQLNRZRFC-ZHACJKMWSA-N
Solubility:
In vitro: 10 mM in DMSO
Appearance:
Light yellow to yellow Solid
Application:
Antineoplastic Agents
Storage: Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Synonyms:
LBH589; LBH 589; LBH-589; NVP-LBH589; NVP-LBH 589; Panobinostat; trade name Farydak

Purity: 98%
Smile code: O=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C=CC=C3)C=C1
MDL Number: MFCD09833242
MolFormula: C21H23N3O2
MolWeight: 349.4300
Available in stock: 19.081

Smile code:
O=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C=CC=C3)C=C1
MDL Number:
MFCD09833242
Purity :
98%
Available in stock:
28.999 g