BGC > Product Search > (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide | 1448297-52-6

Molecular Formula: C22H31ClN4O3S
Molecular Weight: 467.03

Description:
(S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

• Molecular Weight:430.56
• Boiling Point:691.6±55.0 °C at 760 mmHg

Molecular Formula:
C22H30N4O3S
Canonical SMILES:
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O
InChI:
InChI=1S/C22H30N4O3S/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28)/t16-,17+,19-/m1/s1
InChIKey:
ZLOXMSNKPDWMEF-ZIFCJYIRSA-N
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
Synonyms:
MDK7526; VH032-NH2; VHL ligand 1

Purity: 97%
Smile code: O=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
MDL Number: MFCD29049827
MolFormula: C22H30N4O3S
MolWeight: 430.5636
Available in stock: 546.058

Smile code:
O=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
MDL Number:
MFCD29049827
Purity :
97%
Available in stock:
521.457 g