BGC > Product Search > Cyclopamine | 4449-51-8

Molecular Formula: C27H41NO2
Molecular Weight: 411.62
Hazard Symbols: Xi
WGKGermany: 3
HS Code: 29349990

Description:
Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

• Molecular Weight:411.62
• Boiling Point:550.8°C at 760 mmHg
• Melting Point:>235°C (dec.)
• Purity:>98%

Molecular Formula:
C27H41NO2
Canonical SMILES:
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
InChI:
InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChIKey:
QASFUMOKHFSJGL-LAFRSMQTSA-N
Solubility:
Soluble in Chloroform, Dichloromethane, Ethanol (20 mg/mL ), DMSO (4 mg/ml), DMF (10 mg/mL)
Appearance:
White Crystal Powder
Storage: Store at -20°C
Synonyms:
HSDB-3505; HSDB 3505; HSDB-3505; 11-Deoxojervine

Purity: 98%
Smile code: O[C@@H]1CC2=CC[C@]3([H])[C@]([C@@]2(C)CC1)([H])CC4=C(C)[C@@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)CC[C@@]34[H]
MDL Number: MFCD09878269
MolFormula: C27H41NO2
MolWeight: 411.6200
Available in stock: 1.414

Smile code:
O[C@@H]1CC2=CC[C@]3([H])[C@]([C@@]2(C)CC1)([H])CC4=C(C)[C@@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)CC[C@@]34[H]
MDL Number:
MFCD09878269
Purity :
98%
Available in stock:
11.283 g