BGC > Product Search > Bavachinin A | 19879-30-2

Molecular Formula: C21H22O4
Molecular Weight: 338.4
Hazard Symbols: N
UN Number: UN 3077 9 / PGIII
WGKGermany: 3

Molecular Formula: C21H22O4
Molecular Weight: 338.4
Hazard Symbols: N
UN Number: UN 3077 9 / PGIII
WGKGermany: 3

Molecular Formula: C21H22O4
Molecular Weight: 338.4
Hazard Symbols: N
UN Number: UN 3077 9 / PGIII
WGKGermany: 3

Description :
Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model.

• Molecular Weight :338.4
• Boiling Point :537.1±50.0 °C at 760 mmHg
• Melting Point :139-145°C
• Purity :> 98%

Molecular Formula :
C21H22O4
Canonical SMILES :
CC(=CCC1=C(C=C2C(=C1)C(=O)CC(O2)C3=CC=C(C=C3)O)OC)C
InChI :
InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1
InChIKey :
VOCGSQHKPZSIKB-FQEVSTJZSA-N
Appearance :
Powder
Application :
antiinflammatory; antipyretic; analgesic
Synonyms :
7-O-Methylbavachin; Bavachinin A

More details are to be found here

Description :
Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model.

• Molecular Weight :338.4
• Boiling Point :537.1±50.0 °C at 760 mmHg
• Melting Point :139-145°C
• Purity :> 98%

Molecular Formula :
C21H22O4
Canonical SMILES :
CC(=CCC1=C(C=C2C(=C1)C(=O)CC(O2)C3=CC=C(C=C3)O)OC)C
InChI :
InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1
InChIKey :
VOCGSQHKPZSIKB-FQEVSTJZSA-N
Appearance :
Powder
Application :
antiinflammatory; antipyretic; analgesic
Synonyms :
7-O-Methylbavachin; Bavachinin A

More details are to be found here

Description :
Bavachinin is a natural compound isolated from the Chinese herb Fructus Psoraleae. Bavachinin has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. It significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model.

• Molecular Weight :338.4
• Boiling Point :537.1±50.0 °C at 760 mmHg
• Melting Point :139-145°C
• Purity :> 98%

Molecular Formula :
C21H22O4
Canonical SMILES :
CC(=CCC1=C(C=C2C(=C1)C(=O)CC(O2)C3=CC=C(C=C3)O)OC)C
InChI :
InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1
InChIKey :
VOCGSQHKPZSIKB-FQEVSTJZSA-N
Appearance :
Powder
Application :
antiinflammatory; antipyretic; analgesic
Synonyms :
7-O-Methylbavachin; Bavachinin A

More details are to be found here