Description:
SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6.
- Molecular Weight:343.42494
- Purity:>98%
Molecular Formula:
C21H21N5
Canonical SMILES:
CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
InChI:
InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChIKey:
DKPQHFZUICCZHF-UHFFFAOYSA-N
Synonyms:
SB525334; SB-525334; SB 525334 More details are to be found
here