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Suppliers for CAS
1225497-78-8
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Properties | | CAS |
1225497-78-8 | | Formula |
C21H24NNaO8S |
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5 Registered suppliers
Amadis Chemical Company Limited
P.R.China
Leap Chem Co., Ltd
P.R.China
Molecular Formula: C21H24NNaO8S
Molecular Weight: 473.47193
Aea.ltd
P.R.China
Molecular Formula: C21H24NNaO8S
Molecular Weight: 473.47193
Molecular Formula: C21H24NNaO8S
Molecular Weight: 473.47193
BOC Sciences
USA
Description : Rigosertib (ON-01910 sodium salt), a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. - Molecular Weight :473.47
- Melting Point :174-178 °C
Molecular Formula : C21H24NNaO8S Canonical SMILES : COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
InChI :
1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
InChIKey :
VLQLUZFVFXYXQE-USRGLUTNSA-M
Solubility :
Soluble in DMSO
Appearance :
White Solid
Storage : Store at -20 °C
Synonyms :
Glycine, N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, monosodium salt (9CI); (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone sodium salt; Novonex; ON 01910 sodium; ON01910 sodium; ON-01910 sodium; ON 01910 sodium salt; Rigosertib sodium
More details are to be found here
Santa Cruz Biotechnology, Inc.
USA
Description : Rigosertib (ON-01910 sodium salt), a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. - Molecular Weight :473.47
- Melting Point :174-178 °C
Molecular Formula : C21H24NNaO8S Canonical SMILES : COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
InChI :
1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
InChIKey :
VLQLUZFVFXYXQE-USRGLUTNSA-M
Solubility :
Soluble in DMSO
Appearance :
White Solid
Storage : Store at -20 °C
Synonyms :
Glycine, N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, monosodium salt (9CI); (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone sodium salt; Novonex; ON 01910 sodium; ON01910 sodium; ON-01910 sodium; ON 01910 sodium salt; Rigosertib sodium
More details are to be found here
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