BGC > CAS Search > 119509-24-9

Molecular Formula: C15H21Cl2NO5

Molecular Formula: C15H21Cl2NO5

Description :
Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels.

• Molecular Weight :366.2
• Boiling Point :532.59° C at 760 mmHg (Predicted)
• Melting Point :83-86°C
• Purity :≥95%

Molecular Formula :
C15H21Cl2NO5
Canonical SMILES :
CC(CC(C)C(=O)C1=C(C(=C(NC1=O)OC)OC)O)C(CCl)Cl
InChI :
InChI=1S/C15H21Cl2NO5/c1-7(9(17)6-16)5-8(2)11(19)10-12(20)13(22-3)15(23-4)18-14(10)21/h7-9H,5-6H2,1-4H3,(H2,18,20,21)/t7-,8-,9-/m0/s1
InChIKey :
OVULNOOPECCZRG-CIUDSAMLSA-N
Appearance :
White to Off-White Solid
Synonyms :
Antibiotic FO-125A5

More details are to be found here

Description :
Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels.

• Molecular Weight :366.2
• Boiling Point :532.59° C at 760 mmHg (Predicted)
• Melting Point :83-86°C
• Purity :≥95%

Molecular Formula :
C15H21Cl2NO5
Canonical SMILES :
CC(CC(C)C(=O)C1=C(C(=C(NC1=O)OC)OC)O)C(CCl)Cl
InChI :
InChI=1S/C15H21Cl2NO5/c1-7(9(17)6-16)5-8(2)11(19)10-12(20)13(22-3)15(23-4)18-14(10)21/h7-9H,5-6H2,1-4H3,(H2,18,20,21)/t7-,8-,9-/m0/s1
InChIKey :
OVULNOOPECCZRG-CIUDSAMLSA-N
Appearance :
White to Off-White Solid
Synonyms :
Antibiotic FO-125A5

More details are to be found here

Description :
Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels.

• Molecular Weight :366.2
• Boiling Point :532.59° C at 760 mmHg (Predicted)
• Melting Point :83-86°C
• Purity :≥95%

Molecular Formula :
C15H21Cl2NO5
Canonical SMILES :
CC(CC(C)C(=O)C1=C(C(=C(NC1=O)OC)OC)O)C(CCl)Cl
InChI :
InChI=1S/C15H21Cl2NO5/c1-7(9(17)6-16)5-8(2)11(19)10-12(20)13(22-3)15(23-4)18-14(10)21/h7-9H,5-6H2,1-4H3,(H2,18,20,21)/t7-,8-,9-/m0/s1
InChIKey :
OVULNOOPECCZRG-CIUDSAMLSA-N
Appearance :
White to Off-White Solid
Synonyms :
Antibiotic FO-125A5

More details are to be found here